Thermo Fisher Scientific Pierce Traut`s Reagent (2-iminothiolane)

Thermo Fisher Scientific Pierce Traut's Reagent (2-iminothiolane)

Thermo Scientific™ Pierce™ Traut's Reagent (2-iminothiolane) is a small thiolation compound that reacts with primary amines (e.g., lysine side chains) to add a small spacer arm (8.1 Å) terminated by a free sulfhydryl group.

주요 특징

• Simple — One-step conversion of amines to sulfhydryls
• Specific — Selective and spontaneous modification of primary amines at pH 7–10
• Preserves charge — Maintains positive charge to preserve protein solubility
• Flexible — Incorporates a five-atom spacer arm to reduce steric hindrance
• Soluble — Maintains protein solubility by preserving the original positive charge

Traut's Reagent (2-iminothiolane or 2-IT) is a cyclic thioimidate compound used for thiolation (sulfhydryl addition). It reacts with primary amines (—NH₂) to introduce sulfhydryl (—SH) groups while maintaining charge properties similar to the original amino group. Once added, sulfhydryl groups can be specifically targeted for reaction in various labeling, crosslinking, and immobilization procedures.

관련 제품

• Pierce™ SATA

제품 사양