Thermo Fisher Scientific Human TSC1 Synthetic Peptide
Human TSC1 단백질의 C-말단 15개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. TSC1/TSC2 복합체 연구 및 차단 실험에 사용됩니다. 고순도 정제되어 PBS 버퍼에 보관되며, 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PEP0248
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human TSC1.
PEP-0248 can be used as a blocking peptide with polyclonal antibody PA5-20130.
Target Information
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes.
The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase regulating cell growth and cell cycle through integration of nutrient and growth factor signals.
TOR activity is stimulated by Rheb, a Ras superfamily G-protein, when the GTP/GDP ratio bound to Rheb is high.
Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that TSC1/TSC2 decreases Rheb-mediated TOR activation.
Overexpression of TSC1 and TSC2 reduces the GTP/GDP ratio bound to Rheb and inhibits cell growth.
A shorter 40 kDa isoform of TSC1 exists, though its function remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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