Thermo Fisher Scientific Lass4 Polyclonal Antibody
Thermo Fisher Scientific의 Lass4 Polyclonal Antibody는 인간 LASS4 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며, 장기 보관은 -20°C에서 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CERS4 (Accession Q9HA82), corresponding to amino acid residues L49–Q99 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818181 |
Product Specific Information
Antibody detects endogenous levels of total LASS4.
Target Information
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family (LASS1–LASS6) are involved in sphingolipid synthesis.
LASS4 is a 394 amino acid endoplasmic reticulum multi-pass membrane protein that increases levels of long ceramides such as C22:0 and C24:0.
In cells deficient for CLN9, as seen in neuronal ceroid lipofuscinosis (NCL, Batten disease), LASS4 can elevate ceramide levels and partially correct growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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