Thermo Fisher Scientific DNA-PK Polyclonal Antibody
Thermo Fisher Scientific의 DNA-PK Polyclonal Antibody는 인간 DNA-PK 단백질을 인식하는 토끼 유래 IgG 항체입니다. IHC 및 ICC/IF 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PRKDC. Recombinant protein control fragment (Product #RP-97237) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2790417 |
Product Specific Information
Immunogen sequence:
ETLSLMTKEI SSVPCWQFIS WISHMVALLD KDQAVAVQHS VEEITDNYPQ AIVYPFIISS ESYSFKDTST GHKNKEFVAR IK
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase, closely related to PI3 kinases, and often inhibited by small molecules targeting PI3 kinases.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator required for expression of most genes. The mediator complex interacts with transcriptional activators or nuclear receptors to induce gene expression, possibly by engaging RNA polymerase II and promoting formation of a transcriptional pre-initiation complex.
Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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