Thermo Fisher Scientific BST-2 Recombinant Rabbit Monoclonal Antibody (4L6O2)
BST-2 단백질을 표적으로 하는 Thermo Fisher의 재조합 토끼 단클론 항체. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. 높은 특이성과 재현성을 제공하며 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:10,000–1:30,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4L6O2 |
| Immunogen | Recombinant protein of human BST2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3094173 |
Target Information
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein involved in B-cell development and growth. Its surface expression on fibroblast cell lines facilitates stromal cell-dependent growth of pre-B-cell lines. BST2 is highly expressed during B-cell development—from pro-B precursors to plasma cells—as well as in T-cells, monocytes, NK cells, DCs, and myeloma cells.
Research indicates BST2 functions as an inhibitor of retrovirus release from human cells, an activity antagonized by the HIV-1 accessory protein Vpu. BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments. Depletion of BST2 abolishes the viral requirement for Vpu, suggesting potential therapeutic implications for HIV/AIDS. BST2 dysfunction has also been associated with stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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