Thermo Fisher Scientific THEM4 Polyclonal Antibody
THEM4 단백질을 표적하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 IHC에 적합하며, 인간·생쥐·랫트 반응성. 액상 형태로 1 mg/mL 농도, 항원 친화 크로마토그래피로 정제. 연구용으로만 사용 가능.
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Thermo Fisher Scientific THEM4 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the center of human THEM4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153712 |
Product Specific Information
- A suggested positive control is human liver tissue lysate.
- PA5-20773 can be used with blocking peptide PEP-0887.
Target Information
THEM4 (also known as CTMP) binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells.
Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer.
Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase.
Recent reports have also indicated that THEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting involvement in the apoptotic program.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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