Thermo Fisher Scientific PDXK Monoclonal Antibody (1007CT2.1.1)
인간 PDXK 단백질을 인식하는 mouse monoclonal antibody로, Western blot과 IHC(P)에서 검증됨. Protein G로 정제된 액상형 비결합 항체이며, PBS buffer에 sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- MA537743
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:4,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:25
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1007CT2.1.1 |
| Immunogen | Recombinant protein corresponding to amino acids 1–312 of human PDXK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897667 |
Target Information
Pyridoxal kinase (PDXK) converts vitamin B6 to pyridoxal-5-phosphate (PLP), an essential cofactor in amino acid and neurotransmitter metabolism. The PDXK gene encodes a 312-amino acid polypeptide exhibiting pyridoxal kinase activity. A major 1.5-kb transcript is expressed in all tested tissues and shows circadian oscillations. Expression in mouse liver and brain is regulated by PAR bZIP transcription factors (Dbp, Hlf, and Tef), which also oscillate. Mice lacking these factors show reduced brain PLP, serotonin, and dopamine levels, and are prone to spontaneous and audiogenic epilepsies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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