Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (LN-2)

Thermo Fisher Scientific CD74 (B-Cell Marker) Monoclonal Antibody (LN-2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Does not react with Rat.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).
The alpha chain gene contains 5 exons:

• Exon 1 encodes the leader peptide
• Exons 2 and 3 encode the extracellular domains
• Exon 4 encodes the transmembrane domain and cytoplasmic tail

DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. The beta chain contains polymorphisms that determine peptide binding specificity.
Hundreds of DRB1 alleles have been described, and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

HLA-DR is expressed primarily on antigen-presenting cells such as:

• B lymphocytes
• Monocytes
• Macrophages
• Thymic epithelial cells
• Activated T lymphocytes

Three loci (DR, DQ, DP) encode major expressed products of the human class II region.
Human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.