Thermo Fisher Scientific SPRY1 Polyclonal Antibody
SPRY1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며 인간 및 마우스 반응성. 합성 펩타이드 면역원 사용, 액상 형태, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human SPRY1 (aa 35–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2610255 |
Product Specific Information
- Peptide sequence: PTAILSLDQI KAIRGSNEYT EGPSVVKRPA PRTAPRQEKH ERTHEIIPIN
- Sequence homology: Cow 100%, Dog 100%, Guinea Pig 100%, Horse 100%, Human 100%, Mouse 100%, Rabbit 100%, Rat 100%, Zebrafish 100%
Target Information
Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1–4) have been identified. Overexpression of Sprouty-1 and -2 inhibits fibroblast growth factor and vascular endothelial growth factor-induced proliferation and differentiation by repressing MAP kinase activation pathways. Sprouty proteins are endogenous inhibitors of the Ras/MAP kinase pathway and play an important role in tissue remodeling such as lung, kidney tubules, vascular system, and breast ducts. Recent studies suggest Sprouty-1 and -2 may act as tumor suppressors in breast tissue, being consistently down-regulated in breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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