Thermo Fisher Scientific TRAIL-R2 (DR5) Recombinant Rabbit Monoclonal Antibody (131)

Applications

Tested Application and Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody specifically recognizes Mouse TRAIL R2/TNFRSF10B/CD262.

Target Information

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis. It belongs to the TNF receptor superfamily and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis-inducing ligand (TNFSF10/TRAIL/APO-2L), transmitting apoptotic signals.

Studies with FADD-deficient mice indicate that FADD, a death domain adaptor protein, is required for DR5-mediated apoptosis. Multiple transcript variants encoding different isoforms of DR5 have been identified. Overexpression induces apoptosis and activates NF-kappa-B. DR5 is highly expressed in lymphocytes and spleen. Dysregulation is associated with diseases such as squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.