Thermo Fisher Scientific Cystatin M Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Cow: 79%
• Guinea Pig: 86%
• Human: 100%
• Mouse: 79%
• Rabbit: 86%
• Rat: 93%

Target Information

The cystatin superfamily is a well-established family of cysteine protease inhibitors.

• Type 1 (Cystatins A and B): Mainly intracellular
• Type 2 (Cystatins C, D, E/M, F, G, S, SN, SA): Extracellular
• Type 3 (Kininogens): Intravascular proteins

All true cystatins inhibit cysteine peptidases of the papain family (e.g., cathepsins) and some also inhibit legumain family enzymes.
Cystatin SA, S, and SN are found primarily in saliva; S and SN can also be expressed in tears, urine, and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate the inhibition of cathepsin proteins.
The fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis and bone resorption, regulate insulin and hepatocyte growth factor receptors, and modulate systemic inflammation.
High molecular weight kininogen (Kininogen HC) and low molecular weight kininogen (Kininogen LC) both inhibit thrombin- and plasmin-induced aggregation of thrombocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.