Thermo Fisher Scientific Granzyme B (NK/T-Cell Lymphoma Marker) Recombinant Rabbit Monoclonal Antibody (GZMB/4539R)
Granzyme B 표지를 위한 재조합 토끼 단일클론 항체로, NK/T 세포 림프종 연구에 적합합니다. Western blot, IHC, IE 등 다양한 응용 가능하며, 인간 시료에 반응합니다. HEK293 발현 시스템에서 생산되었으며, Protein A/G로 정제된 고순도 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | GZMB/4539R |
| Immunogen | Recombinant fragment of human GZMB protein (around aa 73–187) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4 °C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Stability: Antibody is stable for 24 months.
- Positive Control: A431 cells. Human tonsil, spleen, or Hodgkin’s lymphoma tissue (IHC).
- Cellular Localization: Cytoplasm
Specificity Comments:
Granzyme B is a granule serine protease stored in NK and cytotoxic T cells. It plays a critical role in inducing apoptosis in target cells during immune responses. Granzyme B serves as a useful marker for identifying NK/T-cell lymphomas. High cytotoxic T-cell percentages have been associated with poor prognosis in Hodgkin’s disease.
Target Information
Granzyme B belongs to the granzyme serine protease family and is localized in cytotoxic T cell and NK cell granules. Known also as CGL1 or CTLA-1, it is expressed in activated cytotoxic T lymphocytes. Granzyme B induces apoptosis through caspase-3 activation and mitochondrial pathways (via Bid cleavage). It interacts with the mannose 6-phosphate receptor as a death receptor during cytotoxic T cell-induced apoptosis. Granzymes (A–G in mouse) are neutral serine proteases; in humans, fewer types have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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