Thermo Fisher Scientific CD20/MS4A1 Recombinant Mouse Monoclonal Antibody (rIGEL, 773)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.

Target Information

CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, a subset of T lymphocytes, and follicular dendritic cells.
It regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation.
CD20 is associated with lipid rafts, with its association intensity influenced by extracellular triggers and BCR aggregation.
After receptor ligation, CD20 and BCR colocalize transiently before endocytosis, with CD20 remaining on the cell surface.
CD20 serves as a therapeutic target for B-cell depletion, as it is stably expressed and not internalized after antibody treatment.
Diseases linked to CD20 dysfunction include MS4A1-related common variable immune deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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