Thermo Fisher Scientific CD19 Recombinant Mouse Monoclonal Antibody (rCD19, 4591)

Applications

• Immunohistochemistry (Paraffin) (IHC (P))
  Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.

Target Information

CD19 is a member of the immunoglobulin superfamily with two Ig-like domains. It is expressed on 100% of peripheral B cells and can also be found on myeloid leukemia cells, particularly of monocytic lineage. CD19 serves as a functional regulator of normal and malignant B cell proliferation and is expressed in all B cell precursor leukemias.
It acts as a signal-amplifying coreceptor for the B cell receptor (BCR) and can also signal independently, serving as a central regulatory component for multiple signaling pathways. Mutation of the CD19 gene leads to hypogammaglobulinemia, while overexpression results in B cell hyperactivity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.