Thermo Fisher Scientific Adiponectin Receptor 1 Polyclonal Antibody
Adiponectin Receptor 1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성이 있으며, Protein A 정제 및 고순도 액상 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:300 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Adiponectin Receptor 1 (amino acids 241–270) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that functions as an antidiabetic and anti-atherogenic adipokine. Blood levels of adiponectin decrease under conditions such as obesity, insulin resistance, and type 2 diabetes. Administration of adiponectin lowers glucose levels and improves insulin resistance in mice, while adiponectin-deficient mice exhibit insulin resistance and diabetes.
The insulin-sensitizing effect of adiponectin is mediated by increased fatty-acid oxidation through activation of AMP kinase and PPAR pathways. Adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have been identified, with AdipoR1 highly expressed in skeletal muscle and AdipoR2 predominantly in the liver. These receptors have seven transmembrane domains but differ structurally and functionally from G-protein-coupled receptors. Expression or suppression studies of AdipoR1/R2 confirm their role as receptors for globular and full-length adiponectin, mediating AMP kinase and PPAR ligand activities, fatty-acid oxidation, and glucose uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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