ELK Biotechnology Tie-2 (phospho Tyr992) rabbit pAb

제품명

Tie-2 (phospho Tyr992) rabbit pAb

기본 정보

세포 내 위치

Cell membrane; Single-pass type I membrane protein.
Cell junction; focal adhesion; Cytoplasm, cytoskeleton; Secreted.
Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119).
Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading.
Recruited to the lower surface of migrating cells, especially the rear end of the cell.
Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244).

배경 정보

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family.
The encoded protein possesses a unique extracellular region containing two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains, and three fibronectin type III repeats.
The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway involved in embryonic vascular development.
Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes.
Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants have been described, but their full-length nature is not known. (RefSeq, Feb 2014)