ELK Biotechnology CD89 rabbit pAb
CD89 rabbit pAb는 인간 FCAR 단백질을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. IgA Fc 수용체 연구용으로 사용되며, 다양한 종(Human, Rat, Mouse)에 반응합니다. -20°C에서 1년간 보관 가능합니다.
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제품명
CD89 rabbit pAb
대체 명칭
FCAR; CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD89
적용 분야
WB, IHC, IF, ELISA
권장 희석 배수
- Western Blot: 1/500 - 1/2000
- IHC-p: 1/100 - 1/300
- ELISA: 1/10000
- Other applications: Not yet tested
면역원 (Immunogen)
The antiserum was produced against synthesized peptide derived from the internal region of human FCAR.
Amino acid range: 31–80
제품 사양
| 항목 | 내용 |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 32 kD |
| Gene ID (Human) | 2204 |
| Human Swiss-Prot No | P24071 |
| Species Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Storage | -20°C / 1 year |
세포 내 위치 (Cellular Localization)
- Isoform A.1: Cell membrane; Single-pass type I membrane protein
- Isoform A.2: Cell membrane; Single-pass type I membrane protein
- Isoform A.3: Cell membrane; Single-pass type I membrane protein
- Isoform B: Secreted
- Isoform B-delta-S2: Secreted
배경 (Background)
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)
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