Thermo Fisher Scientific ORL 1 Polyclonal Antibody
Rabbit polyclonal antibody targeting ORL1 (nociceptin receptor); validated for IHC applications. Supplied as a liquid, 1 mg/mL concentration. Suitable for research use in studying GPCR signaling and pain modulation mechanisms.
- 카탈로그번호
- RA14140-100UL
- 판매단위
- pk
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Applications
- Immunohistochemistry (IHC): Tested dilution 10–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide CKTSETVPRPA conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
The G-protein-coupled receptor (GPCR) superfamily comprises an estimated 600–1,000 members and represents the largest known class of molecular targets with proven therapeutic value.
The nociceptin receptor is a G-protein-coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding induces a conformational change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors.
Signaling through G proteins mediates inhibition of adenylate cyclase and calcium channel activities. Arrestins modulate G protein signaling and mediate activation of alternative pathways leading to MAP kinase activation. The receptor plays a role in modulating nociception, perception of pain, and regulation of locomotor activity by nociceptin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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