Thermo Fisher Scientific CISD2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: -

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000
• Publications: -

Product Specifications

Product Specific Information

• Recommended positive controls: Drosophila melanogaster (adult wild type), Cisd2 overexpress (actin promoter)
• Predicted reactivity: Drosophila (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2.
CISD2 is a zinc finger protein localized to the endoplasmic reticulum and mitochondria, binding an iron/sulfur cluster.
It interacts with Bcl-2 and can be displaced by the BH3-only protein BIK, contributing to regulation of BIK-initiated autophagy.
CISD2 deficiency in mice leads to mitochondrial breakdown, autophagic cell death, and premature aging phenotype.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-31955_CISD2_Q9VAM6-1_Rabbit.svg, PA5-31955_CISD2_Q9VAM6-1_Rabbit_PDP.jpeg)