Thermo Fisher Scientific GeneBLAzer CNR1-Gα15-NFAT-bla CHO-K1 Cells
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| K1529 | - | Thermo Fisher Scientific K1529 GeneBLAzer CNR1-Gα15-NFAT-bla CHO-K1 Cells Each pk | 재고문의 | pk | 0원 | - | 0원 | |
다른 상품 둘러보기
Thermo Scientific™
GeneBLAzer™ CNR1-Gα15-NFAT-bla CHO-K1 Cells
GeneBLAzer™ CNR1-Gα15-NFAT-bla CHO-K1 cells contain the human Cannabinoid Receptor 1 (CNR1) stably integrated into the GeneBLAzer™ Gα15-NFAT-bla CHO-K1 cell line.자세히 알아보기
GeneBLAzer™ CNR1-Gα15-NFAT-bla CHO-K1 cells contain the human Cannabinoid Receptor 1 (CNR1) stably integrated into the GeneBLAzer™ Gα15-NFAT-bla CHO-K1 cell line. GeneBLAzer™ Gα15-NFAT-bla CHO-K1 cells (Cat. No. K1537) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Promiscuous G protein, Gα15.
The GeneBLAzer™ CNR1-Gα15-NFAT-bla CHO-K1 cells are functionally validated for Z` and EC50 concentrations of CP-55,940. In addition, GeneBLAzer™ CNR1-Gα15-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The cannabinoid receptors are a family of GPCRs named after their endogenous ligand Delta9-tetrahydrocannabinol (Delta9-THC). Delta9-THC is the psychoactive component of Cannabis sativa (marijuana). CNR1 is present in many tissues throughout the body. The highest concentrations of cannabinoid receptors are in the neurons of the brain, the hippocampus, cerebral cortex, basal ganglia, and the cerebellum. Low-level expression occurs in the lung, testis, and uterus, as well as vascular tissue. Delta9-THC and CP55,940 are endogenous agonists of the CNR1 pathway. Several Delta9-THC and CP55,940 analogs have been synthesized, including HU 210 and WIN 55,212-2. The CNR1 and CNR2 receptors have equal affinity for cannabinoid agonists, but several antagonists that are subtype selective have been synthesized. Examples of these antagonists are AM251, LY-320135, and SR 141716A.
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사양
등록 번호NM_016083
어세이 입력Cell-based beta lactamase reporter gene
셀 상태Dividing Cells
검출 방법Fluorescence
용도(애플리케이션)FRET
유전자 기호CNR1
개체군 상태Single Cell Clone Origin
제품라인GeneBLAzer™
수량2 x 106 Cells
리포터 유전자BLA (Beta-Lactamase)
타겟 입력CNR1
유형CHO-K1 Cells
세포주CHO-K1
System TypeGeneBLAzer™
Druggable TargetGPCR
Unit SizeEach
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