Thermo Fisher Scientific Human MMP-13 Recombinant Protein

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

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Miscellaneous PubMed (Misc)

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View 1 publication 1 publication

Product Specifications

Published species

Not Applicable

Expression System

Insect cells

Class

Recombinant

Type

Protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

-80° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Dry ice

Product Specific Information

RP-77530 is a purified recombinant MMP-13 protein, expressed in Sf9-insect cells using the baculovirus expression vector system. Upon incubation with APMA, active collagenase-3 is formed. RP-77530 may be used as a control with corresponding anti-MMP-13 antibodies.

Target Information

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.