Thermo Fisher Scientific USP19 Polyclonal Antibody

Thermo Fisher Scientific USP19 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.

An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:

• Ubiquitin C-terminal hydrolases
• Ubiquitin-specific processing proteases (USPs)
• OTU-domain ubiquitin-aldehyde-binding proteins
• Jab1/Pad1/MPN-domain-containing metallo-enzymes

Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein and display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.