Thermo Fisher Scientific SQLE Polyclonal Antibody
Human SQLE 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. 콜레스테롤 생합성 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
- Publication: 1 publication available
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SQLE (Product #RP-91199) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at −20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2647904 |
Product Specific Information
Immunogen sequence:
ELHAPLTVVA DGLFSKFRKS LVSNKVSVSS HFVGFLMKNA PQFKANHAEL ILANPSPVLI YQISSSETRV LVDIRGEMPR NLREYMVEKI YPQIPDHLKE PFLEATDNSH LRSMPASFLP PSSVKKRGVL LLGDA
Antigen sequence identity:
- Mouse: 85%
- Rat: 86%
Target Information
SQLE (also known as ERG1, SE, SM) belongs to the squalene monooxygenase family.
It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the steroid structure.
SQLE may serve as a flux-controlling enzyme beyond HMG-CoA reductase (HMGR), and is post-translationally regulated by cholesterol-dependent proteasomal degradation.
The molecular weight of SQLE is approximately 64 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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