Thermo Fisher Scientific GnRHR Polyclonal Antibody
Rabbit polyclonal antibody targeting human GnRHR, validated for IHC and IP applications. High specificity and affinity via antigen affinity purification. Suitable for research use in reproductive hormone signaling studies. Supplied as liquid form, 1 mg...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:3,000
Immunoprecipitation (IP)
- Tested Dilution: Not specified
- Publication: 1 available
In vitro Assay (IV)
- Tested Dilution: Not specified
- Publication: 1 available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human GNRHR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550975 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gibbon (100%); Gorilla, Monkey, Dog, Elephant, Panda (95%); Marmoset, Bovine, Horse, Pig (90%).
Target Information
This gene encodes the receptor for type 1 gonadotropin-releasing hormone (GnRHR). It belongs to the seven-transmembrane, G-protein coupled receptor (GPCR) family and is expressed on pituitary gonadotrope cells, lymphocytes, breast, ovary, and prostate tissues.
Upon binding gonadotropin-releasing hormone, the receptor activates a phosphatidylinositol-calcium second messenger system, leading to the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH).
Defects in this gene can cause hypogonadotropic hypogonadism (HH).
Alternative splicing results in multiple transcript variants, with more than 18 transcription initiation sites in the 5′ region and multiple polyA signals in the 3′ region identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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