Thermo Fisher Scientific GEMIN2 Monoclonal Antibody (OTI4C11), TrueMAB
인간 GEMIN2 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western Blot 및 IHC(Paraffin)에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태, 안정적 저장용 PBS/BSA/glycerol buffer 포함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C11 |
| Immunogen | Full length human recombinant protein of human GEMIN2 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with SMN and is required for formation of the SMN complex. A knockout mouse targeting the homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA showed abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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