Thermo Fisher Scientific HLA-B Polyclonal Antibody
HLA-B 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF 등에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제되어 고순도(>95%) 보장. 연구용으로 면역학 및 이식 관련 연구에 활용 가능.
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- PA587161
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide of human HLA-B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803911 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells.
The heavy chain is approximately 45 kDa and its gene contains 8 exons:
- Exon 1: leader peptide
- Exons 2 and 3: alpha1 and alpha2 domains (peptide binding)
- Exon 4: alpha3 domain
- Exon 5: transmembrane region
- Exons 6 and 7: cytoplasmic tail
Polymorphisms within exon 2 and exon 3 determine peptide binding specificity of each class I molecule. Typing for these polymorphisms is routinely performed for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
HLA and MHC antibodies are crucial in Immunopeptidomics, aiding in the identification and characterization of neoantigens through high-performance liquid chromatography coupled with tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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