Thermo Fisher Scientific Torpedo californica CHRNA1 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:1,000–1:5,000
• Validated in: Direct ELISA

Product Specifications

Product Specific Information

This antibody has been tested in direct-ELISA.

Target Information

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine.
The non-channel linked AChR that mediates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine.

The nAChRs fall into two subclasses:

• Muscle-type receptor: Pentameric glycoprotein of five membrane-spanning subunits (2 alpha1, beta1, gamma or epsilon, and delta) forming a ligand-gated ion channel.
• Neuronal-type receptor: Also a pentamer, composed of alpha and beta subunits (alpha2–alpha8 and beta2–beta4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.