Thermo Fisher Scientific IL-12 p40 Recombinant Rabbit Monoclonal Antibody (23GB5970)
IL-12 p40 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 유세포분석(Flow Cytometry)에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 친화 크로마토그래피 정제 제품입니다. PBS/glycerol buffer에 보관하며 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB5970 |
| Immunogen | A synthesized peptide derived from human IL12B (281–328AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells and has diverse biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of a 40 kDa subunit (encoded by IL12B) and a 35 kDa subunit (encoded by IL12A).
This cytokine is expressed by activated macrophages and is crucial for Th1 cell development and maintenance of memory/effector Th1 cells for long-term immune protection.
Overexpression of IL12B has been observed in the central nervous system of patients with multiple sclerosis (MS), suggesting its role in disease pathogenesis. Promoter polymorphisms of this gene have also been associated with asthma severity in children.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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