Thermo Fisher Scientific UFD1L Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal UFD1L 항체. Western blot, ELISA, Immunoprecipitation에 사용 가능. Affinity chromatography로 정제된 액상 항체로, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified 20 kDa UFD1L protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine residues of target proteins, marking them for degradation by the 26S proteasome. Ub-fusions are processed by Ub-specific proteases (UBps) or the Ub-fusion degradation (UFD) pathway. The UFD pathway targets proteins with substitutions at the C-terminal glycine of Ub.
UFD1, first identified in S. cerevisiae, has a human homolog known as UFD1L. In vitro, UFD1 modulates degradation of Ub-fusions containing substitutions at Gly76 through selective multiubiquitination. Mutations in the UFD1 gene are associated with CATCH22 syndrome, which includes cardiac defects, cleft palate, and hypocalcemia, suggesting a role in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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