Thermo Fisher Scientific PELI1 Monoclonal Antibody (OTI1D9), TrueMAB
PELI1 단백질을 인식하는 마우스 단클론 항체로 Western blot 및 IHC(Paraffin) 검증 완료. 인간 시료에 반응하며, TrueMAB 형식으로 1 mg/mL 농도의 액상 제품. PBS/BSA/glycerol 완충액에 보관되며, 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–245 of human PELI1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways leading to activation of MAP kinases and transcription factors.
Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4–IRAK–TRAF6 complex, resulting in activation of NF-κB.
Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase capable of catalyzing the polyubiquitination of IRAK1.
It is activated via phosphorylation by IRAK1, IRAK4, or IKK-related kinases (IKK-ε, TBK1).
In addition to phosphorylation, Pellino 1 activity is modulated via ubiquitination and sumoylation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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