Thermo Fisher Scientific beta Synuclein Polyclonal Antibody
Thermo Fisher Scientific의 beta Synuclein 폴리클로날 항체로, 인간 및 마우스 시료에 반응합니다. Western Blot과 IHC(Paraffin) 실험에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
- 카탈로그번호
- PA583296
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SNCB. Recombinant protein control fragment (Product #RP-96816). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790452 |
Product Specific Information
Immunogen sequence:
GNIAAATGLV KREEFPTDLK PEEVAQEAAE EPLIEPLMEP EGESYEDPPQ EEYQEYEPEA
Target Information
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates, they are encoded by three different genes. Synucleins have been implicated in major diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and breast cancer.
- In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid.
- In PD, alpha synuclein accumulates in Lewy bodies, and certain alleles are linked to familial PD.
- In breast cancer, increased expression of gamma synuclein correlates with disease progression.
Synucleins may also be involved in membrane plasticity in the developing song control system of songbirds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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