Thermo Fisher Scientific NAT1 Monoclonal Antibody (OTI7G6), TrueMAB
Human NAT1 단백질을 인식하는 마우스 단클론 항체로, Western blot 검증 완료. 1 mg/mL 액상 형태이며, PBS-BSA-glycerol 완충액에 보관. 약물 대사 및 발암 관련 NAT 연구에 적합. 연구용으로만 사용.
- 카탈로그번호
- TA810662
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution
- 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7G6 |
| Immunogen | Full length human recombinant protein of human NAT1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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