Thermo Fisher Scientific APP Monoclonal Antibody (OTI6B7), TrueMAB
인간 APP 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, WB, ICC/IF, Flow Cytometry에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적이며 신경세포 연구 및 알츠하이머 관련 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6B7 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.73 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating axonal transport of beta-secretase and presenilin 1. APP is crucial for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein existing as several isoforms due to alternative splicing. Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, the primary component of senile plaques—one of the major histopathologic features of Alzheimer’s disease. Abnormal APP regulation and processing are implicated in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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