Thermo Fisher Scientific CYP11A1 Polyclonal Antibody
Human CYP11A1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 최적화되어 있습니다. 합성 펩타이드 면역원으로 제작되었으며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제 및 안정적인 PBS/sucrose 버퍼 저장 조건을 갖습니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | |
| Immunohistochemistry (IHC) | 5 µg/mL | |
| Surface Plasmon Resonance (SPR) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human CYP11A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609715 |
Product Specific Information
- Peptide sequence: LRQKGSVHHD YRGILYRLLG DSKMSFEDIK ANVTEMLAGG VDTTSMTLQW
- Sequence homology: Human: 100%
Target Information
CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc, and cytochrome P450 subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under cAMP signal modulation.
CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, regulated by hormonal control of cholesterol availability. Expression of the CYP11A1 gene is controlled by transcription factor SF-1, with the upstream SF-1 binding site required for hormonal stimulation.
c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in interstitial cell monolayers with functional adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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