Thermo Fisher Scientific ATG16L1 Recombinant Rabbit Monoclonal Antibody (JU30-62)
ATG16L1 단백질을 인식하는 토끼 단클론 항체로, Western blot에 최적화됨. 인간, 마우스, 랫트 시료에 반응. HEK293 세포에서 발현된 재조합 항체이며, 단백질 A로 정제됨. 4°C 단기 보관, -20°C 장기 보관 가능.
- 카탈로그번호
- MA545005
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JU30-62 |
| Immunogen | Recombinant protein within N-terminal Human ATG16L1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931459 |
Target Information
Autophagy related protein 16L (ATG16L1) is encoded by the ATG16L gene located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10).
ATG12 and ATG5 conjugate with each other and oligomerize with ATG16L1 to form an ~800 kDa complex known as the Atg16L complex. This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE), a key step in autophagy.
The ATG16L complex, along with other ATG proteins such as ATG18 and ATG21, prevents premature cleavage of ATG8-PE by the cysteine protease Atg4 until autophagosome completion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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