Thermo Fisher Scientific SHROOM1 Polyclonal Antibody
인간 SHROOM1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 완충액에 보관. 신경관 형성과 폐동맥 고혈압 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SHROOM1. Recombinant protein control fragment (Product #RP-96920). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647288 |
Product Specific Information
Immunogen sequence:
VREVLVRALP VEELRVYCAL LAGKAAVLAQ QRNLDERIRL LQDQLDAIRD DLGHHAPSPS PARPPGTCPP VQPPFPLLLT
Highest antigen sequence identity to the following orthologs:
Mouse – 51%, Rat – 51%.
Target Information
SHROOM family members play diverse roles in the development of the nervous system and other tissues.
SHROOM1 is a PDZ domain-containing actin-binding protein required for neural tube morphogenesis.
It facilitates neurulation by regulating the morphology of neurepithelial cells via the apical positioning of an actomyosin network in the neurepithelium.
SHROOM1 is also expressed in pulmonary arterial smooth muscle cells, and its expression is significantly decreased in mouse and human models of pulmonary arterial hypertension, suggesting a potential link between SHROOM1 expression and pulmonary arterial hypertension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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