Thermo Fisher Scientific ARS2 Polyclonal Antibody
Thermo Fisher Scientific의 ARS2 Polyclonal Antibody는 인간 단백질 SRRT에 특이적으로 반응하는 토끼 다클론 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 RNA 조절 및 세포 주기 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SRRT. Recombinant protein control fragment (Product # RP-105101) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791527 |
Product Specific Information
Immunogen sequence:
GLTPGLPYPH QTPQGLMPYG QPRPPILGYG AGAVRPAVPT GGPPYPHAPY GAGRGNYDAF RGQGGYPGKP RNRMVRGDPR AIVEYRDLDA PDDVDFF
Target Information
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs.
Binds capped RNAs (m7GpppG-capped RNA); however, interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal by directly binding the SOX2 promoter and positively regulating its transcription.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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