Thermo Fisher Scientific IMP3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human IMP3 (IGF2BP3) for WB and IP applications. Recognizes residues 1–50 of IGF2BP3. Supplied as liquid, 0.2 mg/mL, stored at 4°C. For research use only.
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- A303425Ax (2개 옵션)
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IMP3 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human Insulin-Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family. It is expressed during embryogenesis and in certain malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is found in a significantly higher proportion of melanomas than Spitz nevi and is more abundant in metastatic melanomas than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in regulating the biological behavior of this tumor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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