Thermo Fisher Scientific NAG-1 Polyclonal Antibody, Biotin
Human NAG-1(GDF15) 단백질에 특이적인 Biotin 결합 폴리클로날 항체로, Western blot, ELISA, IP 등 다양한 응용에 사용 가능. Rabbit IgG 기반으로 고순도 친화 크로마토그래피 정제. 장기보관 시 -20°C에서 안정적.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000 | |
| ELISA | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Affinity purified antibody prepared by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminal end of human NAG-1 protein. A cysteine residue was added to facilitate coupling to KLH. |
| Conjugate | Biotin |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl, 10mg/mL BSA |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at 4°C prior to restoration.
- For extended storage, aliquot contents and freeze at -20°C or below.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antibody specifically reacts with a variant sequence of human NAG-1 protein from human tissues.
A BLAST analysis suggests partial reactivity with NAG-1 from chimpanzee and macaque based on a 92% homology.
Cross-reactivity with NAG-1 from other sources has not been determined.
Target Information
GDF-15 belongs to the TGF-beta cytokine family, which plays an important role in prenatal development, postnatal growth, and tissue remodeling.
It is predominantly expressed in the placenta and, to a lesser extent, in other tissues.
Presence in amniotic fluid and elevated serum levels in pregnant women indicate involvement in gestation and embryonic development.
GDF-15 generally exhibits tumor suppressive activities and is produced in response to p53 pathway activation.
Serum levels correlate with progression of several tumor types, including colorectal, pancreatic, and prostate cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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