Thermo Fisher Scientific MORF4 Monoclonal Antibody (OTI1B12)
MORF4 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 IHC(P)에서 검증됨. Human 시료에 반응하며, 핵 내 전사 억제 관련 연구에 적합. 고순도 Affinity Chromatography 정제 및 안정한 PBS buffer 기반 보존.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–255 of MORF4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723372 |
Target Information
Cellular senescence is the terminal non-dividing state that normal cells enter after completing their proliferative potential. Fusions of immortal human cell lines have led to their classification into four complementation groups. Mortality factor 4 (MORF4) was identified as a key member of a family of transcription factor-like proteins that can reverse the immortal phenotype. Like other members of this family, MORF4 is localized to the nucleus and contains transcription factor-like motifs such as helix-loop-helix and leucine zipper motifs, allowing it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to transcription corepressors mSin3A and TLE, suggesting these complexes may play a role in transcriptional repression of genes involved in cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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