Thermo Fisher Scientific PRKG1 Monoclonal Antibody (2B3)
PRKG1 단백질을 인식하는 mouse monoclonal antibody(2B3)로, WB, IHC, ELISA에 적합. 인간 시료 반응성. PBS buffer 기반 액상 형태로 보존제 무첨가. -20°C에서 보관하며 freeze/thaw를 피해야 함.
- 카탈로그번호
- H00005592-M03
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B3 |
| Immunogen | PRKG1 (NP_006249, 73 a.a. approximately 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
RTKRQAISAE PTAFDIQDLS HVTLPFYPKS PQSKDLIKEA ILDNDFMKNL ELSQIQEIVD CMYPVEYGKD SCIIKEGDVG SLVYVMEDGK VEVTKEGV
Target Information
PRKG1 is a cGMP-dependent serine/threonine kinase which plays an important role in the relaxation of vascular smooth muscle and inhibition of platelet aggregation.
The PRKG1 proteins regulate cardiovascular and neuronal functions, relax smooth muscle tone, and modulate cell growth.
This gene is strongly expressed in smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala.
Isoforms Iα and Iβ have identical cGMP-binding and catalytic domains but differ in leucine/isoleucine zipper and autoinhibitory sequences, resulting in differences in dimerization substrates and kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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