Thermo Fisher Scientific MTHFD2 Monoclonal Antibody (S1)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-Dependent

-

Immunohistochemistry (Paraffin) (IHC (P))

3 µg/mL

-

ELISA (ELISA)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

S1

Immunogen

MTHFD2 (AAH01548, 16 a.a. approximately 344 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: SLRLRPFHLA AVRNEAVVIS GRKLAQQIKQ EVRQEVEEWV ASGNKRPHLS VILVGENPAS HSYVLNKTRA AAVVGINSET IMKPASISEE ELLNLINKLN NDDNVDGLLV QLPLPEHIDE RRICNAVSPD KDVDGFHVIN VGRMCLDQYS MLPATPWGVW EIIKRTGIPT LGKNVVVAGR SKNVGMPIAM LLHTDGAHER PGGDATVTIS HRYTPKEQLK KHTILADIVI SAAGIPNLIT ADMIKEGAAV IDVGINRVHD PVTAKPKLVG DVDFEGVRQK AGYITPVPGG VGPMTVAMLM KNTIIAAKKV LRLEEREVLK SKELGVATN

Target Information

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.