Thermo Fisher Scientific OGG1 Recombinant Rabbit Monoclonal Antibody (ARC1233)
OGG1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ELISA 등에 사용 가능. 인간, 마우스, 랫트 반응성. HEK293 세포에서 발현된 IgG 형 항체이며, 고순도 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Thermo Fisher Scientific OGG1 Recombinant Rabbit Monoclonal Antibody (ARC1233)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1233 |
| Immunogen | Synthetic peptide corresponding to amino acids 246–345 of human OGG1 (UniProt ID: O15527) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.50 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849516 |
Product Specific Information
Immunogen sequence:
VGTKVADCIC LMALDKPQAV PVDVHMWHIA QRDYSWHPTT SQAKGPSPQT NKELGNFFRS LWGPYAGWAQ AVLFSADLRQ SRHAQEPPAK RRKGSKGPEG
Target Information
8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have functional yeast (yOgg1) and human (hOgg1) homologues.
hOgg1 proteins efficiently release 8-hydroxyguanine opposite the pyrimidine from DNA and cleave the AP site similarly to bacterial and yeast enzymes.
Genetic backgrounds controlling DNA damage repair are involved in cancer susceptibility. The hOgg1 gene is mapped to region 3p26.2, showing loss of heterozygosity (LOH) in various cancers, particularly 3p25–p26 in lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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