Thermo Fisher Scientific KIR2DL5B Polyclonal Antibody
인간 KIR2DL5B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, 1 mg/mL 액상 형태로 제공. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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- pk
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KIR2DL5B (Accession Q8NHK3), corresponding to amino acid residues S171–S221 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818536 |
Product Specific Information
Antibody detects endogenous levels of total CD158f2.
Target Information
KIR2DL5A and KIR2DL5B are Killer cell immunoglobulin-like receptors (KIRs), transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.
The KIR genes are polymorphic and highly homologous and are located on chromosome 19q13.4 within the leukocyte receptor complex (LRC).
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain.
Proteins with long cytoplasmic domains transduce inhibitory signals via ITIM motifs, while those with short domains associate with TYRO protein tyrosine kinase binding protein to activate signals.
KIR2DL5A and KIR2DL5B act as NK cell receptors for HLA-C alleles, preventing cell lysis by inhibiting NK cell activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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