Thermo Fisher Scientific N-cadherin Polyclonal Antibody
N-cadherin을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat, Zebrafish 반응성. 고순도 Protein A 정제, 1 mg/mL 농도, 안정적 액상 형태로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human N-cadherin (amino acids 701–800) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
N-cadherin is a 140 kDa transmembrane protein mediating calcium-dependent intercellular adhesion. It plays a key role in morphogenetic movements during development and regulates cell surface adhesion through homotypic interactions. Its function depends on association with the actin-cytoskeleton via the C-terminal region interacting with cytoplasmic catenin proteins. The stability of this complex is regulated by phosphorylation and dephosphorylation of beta-catenin. N-cadherin is composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail, functioning in gastrulation and establishing left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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