Thermo Fisher Scientific LDLRAD4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human LDLRAD4. Validated for Western blot at 1 µg/mL. Recognizes middle region (aa 257-306) of LDLRAD4. Supplied as liquid, 0.5 mg/mL in PBS with 2% sucrose. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human LDLRAD4 (aa 257–306) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2691228 |
Product Specific Information
This target displays homology in the following species:
- Horse: 86%
- Human: 100%
- Mouse: 93%
- Rabbit: 86%
- Rat: 93%
Target Information
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production, and immunosuppression.
In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor.
Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription.
Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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