Thermo Fisher Scientific Human IGF-II Recombinant Protein, PeproTech
Recombinant Human IGF-II 단백질로 세포 증식 및 생존 연구에 사용. E. coli 발현 시스템에서 생산되며 ≥98% 순도 보유. 7.5 kDa 크기의 단백질로, 세포 증식 활성(ED50 ≤ 2.0 ng/ml). 실온 배송, -20°C 보관.
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- Protein
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- pk
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6개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human IGF-II Recombinant Protein, PeproTech
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| ELISA (ELISA) | Assay-dependent | View 2 publications |
| Functional Assay | Assay-dependent | - |
| In vitro Assay | - | View 49 publications |
| Miscellaneous PubMed | - | View 8 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Amphibian, Bovine, Dog, Human, Mouse, Pig, Rat |
| Expression System | E. coli |
| Amino Acid Sequence | AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE |
| Molecular Weight | 7.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 × 10^5 units/mg |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-II is 7.5 kDa.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis.
Target Information
The Insulin-like Growth Factors (IGFs) are mitogenic, polypeptide growth factors that stimulate proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are mainly produced by the liver, but other tissues also produce IGFs at specific times.
IGFs belong to the Insulin gene family, which also includes insulin and relaxin. They are structurally and functionally similar to insulin but exhibit higher growth-promoting activity. IGF-II expression is influenced by placental lactogen, while IGF-I expression is regulated by growth hormone.
Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins containing N-terminal and C-terminal propeptide regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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