Thermo Fisher Scientific CD147/EMMPRIN/Neurothelin Monoclonal Antibody (8D6)

Thermo Fisher Scientific CD147/EMMPRIN/Neurothelin Monoclonal Antibody (8D6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
• Inhibits homotypic aggregation, adhesion to matrix proteins, and migration through Matrigel.

Target Information

CD147 (also known as basigin, neurothelin, OX-47, 5A11, CE9, M6, EMMPRIN, extracellular matrix metalloproteinase inducer, TCSF, tumour cell-derived collagenase-stimulatory factor) is a 50–60 kDa glycoprotein with multiple glycosylated forms.
It is a plasma membrane protein important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. CD147 belongs to the immunoglobulin superfamily and is highly expressed in metabolically active cells such as lymphoblasts, inflammatory cells, brown adipocytes, and malignant tumor cells.
Functions include:

• Facilitating cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases
• Regulating integrin functions
• Roles in cell development and activation, fetal development, and retinal function

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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