Thermo Fisher Scientific AKAP3 Polyclonal Antibody
Human AKAP3 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:500~1:1,000 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 정자 기능 조절 및 암 연구에 적합.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human AKAP3. Recombinant protein control fragment (Product # RP-97690) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2637809 |
Product Specific Information
Immunogen sequence:
AQGGRRDARS FVEAAGTTNF PANEPPVAPD ESCLKSAPIV GDQEQAEKKD LRSVFFNFIR NLLSETIFKR DQSPEPKVPE QPVKEDRKLC ERP
Highest antigen sequence identity to the following orthologs:
- Mouse: 60%
- Rat: 61%
Target Information
The type II cAMP-dependent protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins, designated A-kinase anchoring proteins (AKAP).
AKAP3 (also known as AKAP110, FSP95, PRKA3, and SOB1) binds both PKA and PDE4A and functions as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions. Expression of AKAP3 is restricted to the testis, where bicarbonate stimulates tyrosine phosphorylation of AKAP3, increasing its recruitment of PKA.
AKAP3 also exhibits high expression in epithelial ovarian cancer (EOC) and is associated with worse overall survival, suggesting its potential as a target for antigen-specific immunotherapy in EOC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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