Thermo Fisher Scientific AMICA Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human AMICA. Recombinant protein control fragment (Product #RP-88832). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:AMICA,uniProtId:Q86YT9-1,ncbiNodeId:9606,antigenRange:297-379,antigenLength:394,antigenImageFileName:PA5-61621_AMICA_Q86YT9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61621_AMICA_Q86YT9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637906

Product Specific Information

Immunogen sequence: KKTCGNKSSV NSTVLVKNTK KTNPEIKEKP CHFERCEGEK HIYSPIIVRE VIEEEEPSEK SEATYMTMHP VWPSLRSDRN NSL

Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 42%.

Target Information

AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.